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心理科学进展  2018, Vol. 26 Issue (8): 1429-1437    DOI: 10.3724/SP.J.1042.2018.01429
     研究前沿 本期目录 | 过刊浏览 | 高级检索 |
COMT基因Val158Met多态性与抑郁的关系
刘迪迪,王美萍(),陈翩,张文新
山东师范大学心理学院, 济南 250014
Association between COMT Val158Met polymorphism and depression
Didi LIU,Meiping WANG(),Pian CHEN,Wenxin ZHANG
School of Psychology, Shandong Normal University, Jinan 250014, China
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摘要 

抑郁的发生具有重要的遗传学基础。COMT基因Val158Met多态性是抑郁的重要候选基因位点。目前有关COMT基因Val158Met多态性与抑郁关系的研究主要采用单基因设计、单基因-环境设计以及多基因-环境设计。有资料显示负性情绪偏向及其相关脑区可能在COMT基因Val158Met多态性与抑郁间起中介作用, 但具体机制仍有待探究。未来研究可以进一步考察被试的种族、年龄和性别等因素对COMT基因Val158Met多态性与抑郁关系的调节作用, 并通过采用多基因-环境设计, 综合运用积极与消极环境指标等措施深入考察负性情绪偏向和相关脑区在COMT基因Val158Met多态性与抑郁间的作用及其机制。

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刘迪迪
王美萍
陈翩
张文新
关键词 COMT基因抑郁负性情绪偏向脑机制Val158Met多态性    
Abstract

The development of depression has important genetic underpinnings. COMT (catechol-O- methyltransferase) Val158Met polymorphism is an important candidate gene locus for depression. At present, the studies associated with the relationship between COMT Val158Met polymorphism and depression mainly adopt single gene design, single gene-environment design and multiple gene-environment design. The researches have demonstrated that negativity bias and its related brain mechanism may play an intermediary role between COMT Val158Met polymorphism and depression. However, the mechanism underlying is still not clear and need to be explored. Future research should focus on issues as the moderation effect of participants’ ethnicity, gender and age on the association between COMT Val158Met polymorphism and depression, and further investigate the role of negativity bias and the neuralbiological mechanisms between COMT Val158Met polymorphism and depression by using multiple gene-environment design and comprehensively using positive and negative environmental factors.

Key wordsCOMT gene    depression    negativity bias    brain mechanism    Val158Met polymorphism
收稿日期: 2017-11-26      出版日期: 2018-07-02
ZTFLH:  B845  
基金资助:国家自然科学基金青年项目(31500899);国家自然科学基金面上项目(31671156);山东省社会科学规划研究项目(16CSZJ21)
通讯作者: 王美萍     E-mail: wangmeiping@sdnu.edu.cn
引用本文:   
刘迪迪,王美萍,陈翩,张文新. COMT基因Val158Met多态性与抑郁的关系[J]. 心理科学进展, 2018, 26(8): 1429-1437.
Didi LIU,Meiping WANG,Pian CHEN,Wenxin ZHANG. Association between COMT Val158Met polymorphism and depression. Advances in Psychological Science, 2018, 26(8): 1429-1437.
链接本文:  
http://journal.psych.ac.cn/xlkxjz/CN/10.3724/SP.J.1042.2018.01429      或      http://journal.psych.ac.cn/xlkxjz/CN/Y2018/V26/I8/1429
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