ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2014, Vol. 22 ›› Issue (2): 234-249.doi: 10.3724/SP.J.1042.2014.00234

• 研究前沿 • 上一篇    下一篇

默认网络的神经机制、功能假设及临床应用

李雨;舒华   

  1. 北京师范大学认知神经科学与学习国家重点实验室, 北京 100875
  • 收稿日期:2013-08-09 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 舒华
  • 基金资助:

    国家社科基金重大项目(11&ZD186), 国家自然科学基金项目(31271082), 中央高校基本科研业务费专项基金和北京市自然科学基金项目(7132119)资助。

The Brain Mechanisms and Functional Hypothesis of Default Mode Network and Its Clinical Application

LI Yu;SHU Hua   

  1. National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
  • Received:2013-08-09 Online:2014-02-15 Published:2014-02-15
  • Contact: SHU Hua

PDF (PC)

4494

被引次数

19

摘要：

认知神经科学的迅速发展使得研究者对大脑的功能有了深刻的认识。近些年来, 研究者对大脑在进行外在注意任务时产生的负激活有了更多的了解, 默认网络(Default Mode Network)的概念被提出, 并引起了很多神经科学家的关注, 关于默认网络的相关理论也已提出。当前综述对默认网络的研究历史, 概念理论, 个体和种系发展, 及其与疾病的关系以及临床应用等方面进行了概括总结。未来研究可从默认网络的个体发展, 种系差异, 与其他大脑网络(如注意网络, 视觉网络, 执行控制网络)的关系以及与具体疾病的关系等角度入手进行研究, 共同来探讨默认网络的神经机制。

关键词: 默认网络, 负激活, 功能连接, 临床应用

Abstract:

Rapid development of cognitive neuroscience makes scientists have a deep understanding about human brain function. In recent years, the deactivation phenomenon in some brain areas was commonly observed when participants were required to execute external demanding tasks, and hence the concept of “Default Mode Network (DMN)” was put forward, and has attracted more and more attention from cognitive neuroscientists. Current review mainly focused on the history of DMN research, the relevant concepts and theories, ontogenetic and phylogenetic development, the diseases associated with and its clinical application. It suggests that future studies comprehensively investigate DMN from development trajectory, individual and species differences, the relationships with other brain networks (e.g., attention network, visual network, executive control network), and its associations with diseases.

Key words: default mode network, deactivation, functional connectivity, clinical application