Abstract: A new approach was proposed in which a memory model was studiedwith the method of instrumental enzyme drugs. Two instrumental enzymes, bovine pancreatic Trypsin and RNase, wereselected which are capable of destroying some types of proteins and RNA.A total of 60 adult albino rats, each implanted two pairs of brain canals,were divided into two groups: a non-consolidation group (NC) and a cons-olidation group (C). Each group was again divided into three sub-groupsof Trypsin (T), RNase (R) and normal saline salution (NS). The resultsshowed that after different periods of bilateral injection of Trypsin andRNase into the hippocampus (iH), different effects were observed on theconditioned reflex of DBA memory model(CR_(DBA)). 72 hours after injectionof Trypsin (AP_2L_2H_4 and AP_4L_3H_5) retention of DBA memory clearlydecreased in the NC group, and the amnesia effect under this experimentalcondition contrasted with the other conditions in that their differences werestatistically significant. The paper discussed on some possible causes of the above phenomenonas well as the significance of the experimental findings. The authors wereof the opinion that if instrumental enzyme drugs with clearly demonstratedactive mechanisms could be selected systematically and to pursue furtherresearch into the influences of drugs on the consolidation of different levelsof memory model, it would be of benefit to the understanding of the bra-inchemical mechanism of memory. At least this would be a new line ofapproach that is worth exploration.

Key words: NULL